Slavis S A, Scholz J N, Hewitt C W, Black K S, Campbell R S, Patel M, Zimmerman J, Peake M L, Martin D C
Department of Surgery, University of California, Irvine 92717.
J Urol. 1990 Mar;143(3):638-41. doi: 10.1016/s0022-5347(17)40046-2.
Adult male Lewis (LEW) rats were used to investigate the effects of unilateral testicular trauma on fertility. Comparisons were made between normal and experimental rats immunized with syngeneic sperm in Complete Freund's Adjuvant (CFA). Matings within the three groups yielded offspring to all normal males, no offspring to the immunized rats, and 27% (3/11) fertility in the trauma group (p less than 0.001). The contralateral testis demonstrated decreased volumes, various degrees of aspermatogenesis and smaller seminiferous tubular diameters, in both the trauma and immunized groups compared to the controls. Similar histopathologic findings of chronic granulomatous inflammation within contralateral testes in both the trauma and immunized groups suggested a common immune etiology for infertility via possible disruption of the blood-testis barrier.
成年雄性Lewis（LEW）大鼠被用于研究单侧睾丸创伤对生育能力的影响。对正常大鼠和用完全弗氏佐剂（CFA）中的同基因精子免疫的实验大鼠进行了比较。三组内的交配结果显示，所有正常雄性大鼠都能产生后代，免疫大鼠没有后代，创伤组的生育能力为27%（3/11）（p<0.001）。与对照组相比，创伤组和免疫组的对侧睾丸体积减小，出现不同程度的无精子症，生精小管直径变小。创伤组和免疫组对侧睾丸均出现慢性肉芽肿性炎症的类似组织病理学发现，提示可能通过血睾屏障破坏导致不育的共同免疫病因。
