Kalsner S
Can J Physiol Pharmacol. 1977 Aug;55(4):882-7. doi: 10.1139/y77-117.
The relationship between bath Po2, intramural prostaglandin synthesis, and vessel tone in isolated coronary arteries of cattle was studied. The basal output of prostaglandin under 95% O2-5% CO2 (580 mmHg) was elevated markedly when the Po2 was decreased to 47 mmHg but extreme hypoxia (9 mmHg) sharply curtailed output. The coronary vessels responded to 47 mmHg with relaxation but they contracted when the Po2 was decreased further to 9 mmHg. Known inhibitors of prostaglandin synthesis attenuated both the hypoxia-induced relaxations and contractions. Analysis of the effects of extreme hypoxia and of inhibitors of prostaglandin synthesis on tone indicated that both suppress prostaglandin production. It is concluded that coronary prostaglandin synthesis is accelerated by hypoxia unless the oxygen deprivation is so severe as to limit the availability of oxygen for synthesis.
研究了牛离体冠状动脉中浴氧分压（Po2）、壁内前列腺素合成与血管张力之间的关系。在95%氧气 - 5%二氧化碳（580 mmHg）条件下，前列腺素的基础产量在Po2降至47 mmHg时显著升高，但极端低氧（9 mmHg）时产量急剧减少。冠状动脉对47 mmHg的反应是舒张，但当Po2进一步降至9 mmHg时则收缩。已知的前列腺素合成抑制剂可减弱低氧诱导的舒张和收缩。对极端低氧和前列腺素合成抑制剂对张力的影响分析表明，二者均抑制前列腺素的产生。结论是，除非缺氧严重到限制合成所需氧气的供应，否则低氧会加速冠状动脉前列腺素的合成。
