Kirkinen P, Heinonen S, Vanamo K, Ryynänen M
Department of Obstetrics and Gynaecology, University of Kuopio, Finland.
Prenat Diagn. 1997 Jan;17(1):47-50. doi: 10.1002/(sici)1097-0223(199701)17:1<47::aid-pd19>3.0.co;2-i.
Maternal serum alpha-fetoprotein (AFP) and total beta-human chorionic gonadotrophin (hCG) concentrations were measured at the 15th gestational week in ten pregnancies complicated by fetal sacrococcygeal teratoma. The findings corresponded to those in normal pregnancies. Similarly, third-trimester concentrations of cancer antigen 12-5, tumour-associated trypsin inhibitor, and the amino-terminal propeptide of type III procollagen in the maternal serum were not significantly elevated. Histologically mature and immature/malignant cases did not differ from each other as regards the above-mentioned parameters. This abnormality cannot be detected by maternal serum trisomy screening in the second trimester.
在10例合并胎儿骶尾部畸胎瘤的妊娠中，于妊娠第15周测定了母血清甲胎蛋白（AFP）和总β-人绒毛膜促性腺激素（hCG）浓度。结果与正常妊娠者相符。同样，孕晚期母血清中癌抗原12-5、肿瘤相关胰蛋白酶抑制剂和III型前胶原氨基端前肽的浓度也未显著升高。在上述参数方面，组织学成熟与未成熟/恶性病例之间无差异。在孕中期进行的母血清三体筛查无法检测出这种异常情况。
