Jira W, Spiteller G, Schramm A
Lehrstuhl für Organische Chemie I, Universität Bayreuth, Germany.
Chem Phys Lipids. 1996 Dec 20;84(2):165-73. doi: 10.1016/s0009-3084(96)02635-7.
The content of hydroxy fatty acids in low density lipoprotein (LDL) of healthy volunteers aged between 22 and 87 years without any signs of atherosclerosis or other age-dependent diseases was investigated. The level of hydroxy fatty acids obtained from LDL increases during life time: clinically healthy persons between 56 and 66 years showed a 3- to 4-fold increase compared to young volunteers. This level increased in samples of probands aged 68 to 74 years compared to samples of young people for a factor of 10-20 and in samples of probands aged 78 to 87 years for a factor of 30-40. These hydroxy acids--generated mainly from hydroperoxy acids on linoleic acid and only partly from arachidonic acid--are obviously parameters of the LDL oxidation stage. About 90% of the total amount of hydroxy fatty acid were free fatty acids. The distribution patterns of the monohydroxy derivatives of linoleic and arachidonic acid indicate that they originate mainly from autocatalytic processes. The individual level of hydroxy acids is probably an indicator of the biological age.
对年龄在22至87岁之间、无任何动脉粥样硬化迹象或其他与年龄相关疾病的健康志愿者的低密度脂蛋白（LDL）中的羟基脂肪酸含量进行了研究。从LDL中获得的羟基脂肪酸水平在一生中会升高：56至66岁的临床健康者与年轻志愿者相比，其水平升高了3至4倍。与年轻人的样本相比，68至74岁先证者样本中的这一水平升高了10至20倍，而78至87岁先证者样本中的这一水平升高了30至40倍。这些羟基酸——主要由亚油酸上的氢过氧酸生成，仅部分由花生四烯酸生成——显然是LDL氧化阶段的参数。羟基脂肪酸总量的约90%为游离脂肪酸。亚油酸和花生四烯酸单羟基衍生物的分布模式表明它们主要源自自催化过程。羟基酸的个体水平可能是生物学年龄的一个指标。
