Shatwell K P, Segal A W
Department of Medicine, University College London, Rayne Institute, U.K.
Int J Biochem Cell Biol. 1996 Nov;28(11):1191-5. doi: 10.1016/s1357-2725(96)00084-2.
Superoxide is instrumental in the killing of microorganisms by phagocytic cells. It is generated by the NADPH oxidase system, a membrane-bound electron transport complex which pumps electrons from NADPH in the cytoplasm across the wall of the phagocytic vacuole to molecular oxygen. Superoxide deficiency results in the genetically inherited condition Chronic Granulomatous Disease (CGD), in which the patient is abnormally susceptible to infection. In recent years many of the underlying genetic defects in CGD have been identified and are providing important insights into the structure and mechanism of the NADPH oxidase complex.
超氧化物在吞噬细胞杀灭微生物的过程中发挥着重要作用。它由NADPH氧化酶系统产生，这是一种膜结合电子传递复合体，可将细胞质中的NADPH电子泵过吞噬泡壁传递给分子氧。超氧化物缺乏会导致遗传性疾病慢性肉芽肿病（CGD），患者对感染异常易感。近年来，已确定了CGD的许多潜在遗传缺陷，这为深入了解NADPH氧化酶复合体的结构和机制提供了重要线索。
