Kakati S, Song S Y, Sandberg A A
Cancer. 1977 Sep;40(3):1173-81. doi: 10.1002/1097-0142(197709)40:3<1173::aid-cncr2820400328>3.0.co;2-t.
Detailed karyotypic analysis with G- and C-banding has been performed on cells of four malignant melanomas. The modal number in two cases was in the hypodiploid range, the chromosome numbers varying from 39 to 43. These two tumors had 5 to 13 marker chromosomes. The other two tumors were in the polyploid range, with modal numbers of 63 to 157 chromosomes. The cells had a minimum of 11 and a maximum of 40 marker chromosomes. Chromosome no. 1 was more frequently involved in aberrations than any other chromosome. The most common breakpoints on this chromosome were 1q21, 1q25 and 1q32. Frequent breakpoints were also noticed in the centromeric region in various chromosomes. In chromosome no. 1, however, the centromeric area does not seem to be involved. The more common breakpoints on the various chromosomes were 1q21, 1q25, 1q32, 5p13, 9q13, 11q23, 12q13. No common markers were noticed among these four cases of melanoma, but are noticed in unrelated tumors.
已对4例恶性黑色素瘤细胞进行了G显带和C显带的详细核型分析。2例的众数在亚二倍体范围内，染色体数在39至43之间变化。这2个肿瘤有5至13条标记染色体。另外2个肿瘤处于多倍体范围内，众数为63至157条染色体。细胞最少有11条、最多有40条标记染色体。1号染色体比其他任何染色体更常出现畸变。该染色体上最常见的断点是1q21、1q25和1q32。在各种染色体的着丝粒区域也发现了频繁的断点。然而，在1号染色体中，着丝粒区域似乎未受累。各种染色体上更常见的断点是1q21、1q25、1q32、5p13、9q13、11q23、12q13。在这4例黑色素瘤病例中未发现共同的标记，但在无关肿瘤中发现了。
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