Ozisik Y Y, Meloni A M, Altungoz O, Peier A, Karakousis C, Leong S P, Sandberg A A
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Cancer Genet Cytogenet. 1994 Oct;77(1):69-73. doi: 10.1016/0165-4608(94)90152-x.
Cytogenetic analysis was performed on 21 tumor samples of malignant melanoma to identify the presence of consistent chromosome abnormalities. Four cases had a normal karyotype, and 17 were cytogenetically abnormal. Numerical chromosome alterations were observed in 15 tumors: 12 were hyperdiploid and three were hypodiploid. The most frequent losses consisted of chromosomes 5, 9, 17 and Y. The structural abnormalities were usually complex, consisting mainly of nonreciprocal translocations and deletions affecting 1p, 1q, 3p, and 9p. This study adds further data to previously reported melanoma cases, confirming that chromosomes 1, 3, 6, and 9 are nonrandomly affected.
对21例恶性黑色素瘤肿瘤样本进行了细胞遗传学分析，以确定是否存在一致的染色体异常。4例核型正常，17例存在细胞遗传学异常。在15个肿瘤中观察到染色体数目改变：12个为超二倍体，3个为亚二倍体。最常见的缺失包括5号、9号、17号染色体和Y染色体。结构异常通常很复杂，主要包括影响1p、1q、3p和9p的非相互易位和缺失。本研究为先前报道的黑色素瘤病例增加了更多数据，证实1号、3号、6号和9号染色体受到非随机影响。
