Saltzstein S L, McLaughlin A P
Cancer. 1977 Sep;40(3):1212-21. doi: 10.1002/1097-0142(197709)40:3<1212::aid-cncr2820400335>3.0.co;2-6.
Histologic features of the primary tumor and their effects on the incidence of unsuspected pelvic lymph node metastases have been studied in a prospective series of 62 patients with clinical stage B1, B2, or C prostatic adenocarcinoma who underwent pelvic lymph node removal. Twenty-one patients (34%) proved to have unsuspected nodal metastases. Differentiation of the primary tumor and extent of involvement of the prostate by carcinoma were the only two features that correlated significantly with the incidence of pelvic nodal metastases, 56% of those with undifferentiated tumors had metastases. Thirty-one of these patients underwent total prostatectomy; an average of only 46% of the sections of prostate contained tumor in the patients without metastases but an average of 65% of the sections were involved by carcinoma in those patients who did have nodal metastases.
在一项对62例临床分期为B1、B2或C期前列腺腺癌且接受盆腔淋巴结清扫术的患者进行的前瞻性研究中，对原发性肿瘤的组织学特征及其对未被怀疑的盆腔淋巴结转移发生率的影响进行了研究。21例患者（34%）被证实存在未被怀疑的淋巴结转移。原发性肿瘤的分化程度和前列腺癌的累及范围是仅有的两个与盆腔淋巴结转移发生率显著相关的特征，56%的未分化肿瘤患者发生了转移。其中31例患者接受了前列腺全切术；在无转移的患者中，前列腺切片平均仅有46%含有肿瘤，但在有淋巴结转移的患者中，平均65%的切片被癌累及。
