通过局部应用N-亚硝基双（2-羟丙基）胺和N-亚硝基双（2-乙酰氧基丙基）胺诱导上皮肿瘤
Induction of epithelial neoplasms by local application of N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-acetoxypropyl)amine.
作者信息
Pour P, Althoff J, Nagel D
出版信息
Cancer Lett. 1977 Sep;3(3-4):109-13. doi: 10.1016/s0304-3835(77)94760-7.
The local carcinogenic effect of N-nitrosobis(2-hydroxypropyl)amine (BHP) and N-nitrosobis(2-acetoxypropyl)amine (BAP) in Syrian golden hamsters was elucidated by weekly application to the cheek pouch, lip and vaginal epithelium. The tumor type and incidence in BHP- and BAP-treated hamsters, respectively, was as follows: trichoepitheliomas of the lip, 80 and 90%; cheek pouch papillomas, 10 and 0%, and vaginal papillomas, 80 and 70%. Other lesions were recorded in the perineum, rectum and external urethral ostium and could have been due to a local effect of these nitrosamines. In addition, internal organ tumors were observed with each compound and were possibly caused by absorption of the carcinogens.
通过每周将N-亚硝基双（2-羟丙基）胺（BHP）和N-亚硝基双（2-乙酰氧基丙基）胺（BAP）涂抹于叙利亚金仓鼠的颊囊、唇部和阴道上皮，阐明了它们的局部致癌作用。BHP和BAP处理的仓鼠的肿瘤类型和发生率分别如下：唇部毛发上皮瘤，80%和90%；颊囊乳头状瘤，10%和0%，以及阴道乳头状瘤，80%和70%。在会阴、直肠和尿道外口记录到了其他病变，可能是这些亚硝胺的局部作用所致。此外，每种化合物都观察到了内部器官肿瘤，可能是致癌物吸收所致。
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