Hoover R L, Lynch R D, Karnovsky M J
Cell. 1977 Sep;12(1):295-300. doi: 10.1016/0092-8674(77)90207-0.
The addition of long chain unsaturated fatty acids (linoleic, linolenic and arachidonic acids) to BHK cells reduces the cell to substrate adhesion, causes morphological changes and alters the cellular growth properties. The new characteristics are similar to those of transformed cells. The data indicate that the effects are probably due to actual changes in the surface membrane lipids and not due to prostaglandin synthesis.
向幼仓鼠肾（BHK）细胞中添加长链不饱和脂肪酸（亚油酸、亚麻酸和花生四烯酸）会降低细胞与底物的粘附力，引起形态变化并改变细胞生长特性。这些新特性与转化细胞的特性相似。数据表明，这些影响可能是由于表面膜脂质的实际变化，而非前列腺素合成所致。
