不饱和脂肪酸延长大鼠妊娠期。
Prolongation of rat gestation time by unsaturated fatty acids.
作者信息
Waltman R, Tricomi V, Shabanah E H, Arenas R
出版信息
Am J Obstet Gynecol. 1978 Aug 1;131(7):735-8. doi: 10.1016/0002-9378(78)90236-3.
Arachidonic, linoleic, linolenic, and oleic acids, administered to Sprague-Dawley rats on Days 20 and 21 of gestation prolonged the gestation time; neither the duration parturition, parturitional bleeding, nor the perinatal mortality rate was affected. Since arachidonic acid is the obligatory precursor of prostaglandins E2 and F2 alpha, currently believed to be associated with the initiation of labor, and polyunsaturated fatty acids inhibit the cell-mediated immune response in vivo, the precise role of prostaglandins and their precursors in the initiation of parturition must be critically examined.
在妊娠第20天和第21天给斯普拉格-道利大鼠施用花生四烯酸、亚油酸、亚麻酸和油酸会延长妊娠期；分娩持续时间、分娩出血和围产期死亡率均未受影响。由于花生四烯酸是目前认为与分娩发动有关的前列腺素E2和F2α的必需前体，并且多不饱和脂肪酸在体内会抑制细胞介导的免疫反应，因此必须严格审查前列腺素及其前体在分娩发动中的精确作用。
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