枯草芽孢杆菌gerC操纵子的两个顺反子编码了庚二烯基二磷酸合酶的两个亚基。
Two cistrons of the gerC operon of Bacillus subtilis encode the two subunits of heptaprenyl diphosphate synthase.
作者信息
Zhang Y W, Koyama T, Ogura K
机构信息
Institute for Chemical Reaction Science, Tohoku University, Aoba-ku, Sendai, Japan.
出版信息
J Bacteriol. 1997 Feb;179(4):1417-9. doi: 10.1128/jb.179.4.1417-1419.1997.
Abstract
The two proteins (GerC1 and GerC3) encoded by the gerC locus of Bacillus subtilis, which has been shown to be involved in vegetative cell growth and spore germination, were identified as dissociable heterodimers of the heptaprenyl diphosphate synthase involved in the biosynthesis of the side chain of menaquinone-7.
摘要
枯草芽孢杆菌gerC基因座编码的两种蛋白质（GerC1和GerC3）已被证明参与营养细胞生长和孢子萌发，它们被鉴定为参与甲萘醌-7侧链生物合成的庚基二磷酸合酶的可解离异二聚体。
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Two cistrons of the gerC operon of Bacillus subtilis encode the two subunits of heptaprenyl diphosphate synthase.枯草芽孢杆菌gerC操纵子的两个顺反子编码了庚二烯基二磷酸合酶的两个亚基。
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本文引用的文献
1
Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase.嗜热脂肪芽孢杆菌法呢基二磷酸合酶底物结合位点中重要残基的鉴定
Biochemistry. 1996 Jul 23;35(29):9533-8. doi: 10.1021/bi960137v.
2
Thermostable farnesyl diphosphate synthase of Bacillus stearothermophilus: molecular cloning, sequence determination, overproduction, and purification.嗜热脂肪芽孢杆菌的耐热法呢基二磷酸合酶：分子克隆、序列测定、过量表达及纯化
J Biochem. 1993 Mar;113(3):355-63. doi: 10.1093/oxfordjournals.jbchem.a124051.
3
4
Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity.保守天冬氨酸和精氨酸残基的定点诱变对法呢基二磷酸合酶活性的影响。
J Biol Chem. 1993 Dec 25;268(36):26983-9.
5
Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II.酵母法尼基二磷酸合酶：对高度保守的异戊二烯基转移酶结构域I和II中的残基进行定点诱变。
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3044-8. doi: 10.1073/pnas.91.8.3044.
6
Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components.藤黄微球菌B-P 26的六异戊二烯基焦磷酸合成酶。两种必需成分的分离。
J Biol Chem. 1982 Dec 25;257(24):14610-2.
7
Heptaprenyl pyrophosphate synthetase from Bacillus subtilis.来自枯草芽孢杆菌的庚基焦磷酸合成酶。
J Biol Chem. 1980 May 25;255(10):4539-43.
8
Essential protein factors for polyprenyl pyrophosphate synthetases. Separation of heptaprenyl pyrophosphate synthetase into two components.
FEBS Lett. 1983 Sep 19;161(2):257-60. doi: 10.1016/0014-5793(83)81020-5.
9
Dynamic interaction between components of hexaprenyl diphosphate synthase from Micrococcus luteus BP-26.
Biochemistry. 1987 Oct 20;26(21):6840-5. doi: 10.1021/bi00395a038.
10
Formation of a stable and catalytically active complex of the two essential components of hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26.藤黄微球菌B-P 26中六异戊二烯基二磷酸合酶的两个必需组分形成稳定且具有催化活性的复合物。
Biochem Biophys Res Commun. 1989 Apr 28;160(2):448-52. doi: 10.1016/0006-291x(89)92453-4.
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