藤黄微球菌B-P 26六异戊二烯基二磷酸合酶两种必需蛋白质成分编码基因的分子克隆、表达及特性分析
Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase.
作者信息
Shimizu N, Koyama T, Ogura K
机构信息
Institute for Chemical Reaction Science, Tohoku University, Sendai, Japan.
出版信息
J Bacteriol. 1998 Mar;180(6):1578-81. doi: 10.1128/JB.180.6.1578-1581.1998.
Abstract
The structural genes encoding the two essential components A and B of hexaprenyl diphosphate synthase, which produce the precursor of the prenyl side chain of menaquinone-6, were cloned from Micrococcus luteus B-P 26.
摘要
从藤黄微球菌B-P 26中克隆出编码六异戊二烯基二磷酸合酶两个必需组分A和B的结构基因，该酶可生成甲基萘醌-6异戊二烯侧链的前体。
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J Biol Chem. 1997 May 9;272(19):12380-3. doi: 10.1074/jbc.272.19.12380.
2
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