Bowker K E, Holt H A, Reeves D S, MacGowan A P
Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust, UK.
J Antimicrob Chemother. 1996 Dec;38(6):1055-60. doi: 10.1093/jac/38.6.1055.
The effect of increasing meropenem concentrations up to 250 mg/L, as might occur if 3 g was given as a single daily intravenous dose, was investigated in terms of bactericidal activity, post antibiotic effect (PAE) and modified controlled effective regrowth time (mCERT). Increasing the meropenem concentration above 50 mg/L did not result in increased bacterial killing, while concentrations over 75 mg/L did not result in longer PAE or mCERT.
