Morrissey I
Chemotherapy Research Unit, University of East London, UK.
J Antimicrob Chemother. 1996 Dec;38(6):1061-6. doi: 10.1093/jac/38.6.1061.
Trovafloxacin was found to be a typical quinolone producing a biphasic dose response against Escherichia coli, Staphylococcus aureus or Streptococcus pneumoniae. A reduced rate of kill was seen against Enterococcus faecalis, which is also typical of the quinolones. However, the bactericidal activity of trovafloxacin against S. aureus and S. pneumoniae was greater than most other quinolones previously tested. The enhanced bactericidal activity of trovafloxacin against S. aureus may be explained by the possession of a very strong bactericidal mechanism B. Trovafloxacin may prove to be a quinolone of choice against S. aureus infections.
发现曲伐沙星是一种典型的喹诺酮类药物，对大肠杆菌、金黄色葡萄球菌或肺炎链球菌产生双相剂量反应。对粪肠球菌的杀菌速率降低，这也是喹诺酮类药物的典型特征。然而，曲伐沙星对金黄色葡萄球菌和肺炎链球菌的杀菌活性高于大多数先前测试的其他喹诺酮类药物。曲伐沙星对金黄色葡萄球菌增强的杀菌活性可能是由于拥有非常强大的杀菌机制B。曲伐沙星可能被证明是治疗金黄色葡萄球菌感染的首选喹诺酮类药物。
