抗真菌抗生素贝纳霉素A与两性霉素B的体外活性比较。

The in-vitro activity of an antifungal antibiotic benanomicin A in comparison with amphotericin B.

作者信息

Watanabe M, Hiratani T, Uchida K, Ohtsuka K, Watabe H, Inouye S, Kondo S, Takeuchi T, Yamaguchi H

机构信息

Research Center for Medical Mycology, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

J Antimicrob Chemother. 1996 Dec;38(6):1073-7. doi: 10.1093/jac/38.6.1073.

DOI:10.1093/jac/38.6.1073

PMID:9023656

Abstract

Benanomicin A showed a broad antifungal spectrum, inhibiting the growth of all test strains of 41 yeasts, 23 dimorphic fungi, 23 dematiaceous fungi, 16 aspergilli, and 19 dermatophytes, with the exception of 12 zygomycetic strains. The MIC values of benanomicin A were comparable to those of amphotericin B against Cryptococcus. Rhodotorula, Trichosporon, Geotrichum, Sporothrix, and some dermatophytes, but were two to eightfold higher than those of amphotericin B against other fungal pathogens tested. The action of benanomicin A was fungicidal.

摘要

贝纳诺霉素A显示出广泛的抗真菌谱，能抑制41种酵母、23种双相真菌、23种暗色真菌、16种曲霉菌和19种皮肤癣菌的所有测试菌株的生长，但对12种接合菌菌株无效。贝纳诺霉素A对隐球菌、红酵母、毛孢子菌、地霉、申克孢子丝菌和一些皮肤癣菌的最低抑菌浓度（MIC）值与两性霉素B相当，但对其他测试真菌病原体的MIC值比两性霉素B高2至8倍。贝纳诺霉素A的作用是杀菌性的。