Hubert J, Kerboeuf D, Cardinaud B, Blond-Riou F, Fournier R
INRA Station de Pathologie Aviaire et de Parasitologie, Unité d'Helminthologie, Nouzilly, France.
Vet Parasitol. 1997 Jan;68(1-2):187-90. doi: 10.1016/s0304-4017(96)01066-7.
The persistent activity of moxidectin topically administered at the dose rate of 0.5 mg kg-1 bodyweight was evaluated against experimental nematode infection in 30 calves randomly allocated to six groups. Five groups were treated on days -42, -35, -28, -21 and -14. The 6th group remained untreated as a control. On Day 0, the calves were infected experimentally with 1000 Dictyocaulus viviparus and 50,000 Ostertagia ostertagi larvae and killed 3 weeks later. The formulation of moxidectin showed excellent activity against both parasites for up to 5 weeks (> 99%). Six weeks after treatment the reduction in the number of D. viviparus was still high (> 90%). No adverse reactions to moxidectin were observed in any of the animals.
