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作为V-ATP酶和P-ATP酶抑制剂的巴弗洛霉素和 concanamycin

Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases.

作者信息

Dröse S, Altendorf K

机构信息

Universität Osnabrück, Fachbereich Biologie/Chemie, Germany.

出版信息

J Exp Biol. 1997 Jan;200(Pt 1):1-8. doi: 10.1242/jeb.200.1.1.

DOI:10.1242/jeb.200.1.1
PMID:9023991
Abstract

Bafilomycins and concanamycins, two groups of the plecomacrolide-defined class of macrolide antibiotics, have recently been recognized as important tools for studying the physiological role of vacuolar-type, proton-translocating ATPases (V-ATPases) and ATPases with phosphorylated states (P-ATPases) in animal and plant cells as well as in yeast, fungi and bacteria. The following review will give an account of the classification and function of these antibiotics.

摘要

巴弗洛霉素和抗霉素，这两类属于多烯大环内酯类定义的大环内酯抗生素，最近被认为是研究液泡型质子转运ATP酶（V-ATP酶）和磷酸化状态的ATP酶（P-ATP酶）在动物、植物细胞以及酵母、真菌和细菌中的生理作用的重要工具。以下综述将介绍这些抗生素的分类和功能。

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