Blomqvist N, Cederblad G, Korsan-Bengtsen K, Wallerstedt S
Clin Chem. 1977 Oct;23(10):1845-8.
When studying the correlation between the change of a variable during treatment and the value before treatment, random errors (errors of measurement as well as intra-individual biological variation) may yield seriously biased results. In the present work a method to adjust for this bias is presented. The method was applied to data from blood coagulation factor and plasma protein analyses in chronic alcoholics before and after one week of abstinence. It was found that many of the significant correlations were lost when the data were adjusted.
在研究治疗期间变量的变化与治疗前的值之间的相关性时，随机误差（测量误差以及个体内生物变异）可能会产生严重有偏差的结果。在本研究中，提出了一种校正这种偏差的方法。该方法应用于慢性酒精中毒患者戒酒一周前后凝血因子和血浆蛋白分析的数据。结果发现，对数据进行校正后，许多显著的相关性消失了。
