Hillis S D, Owens L M, Marchbanks P A, Amsterdam L F, Mac Kenzie W R
Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Am J Obstet Gynecol. 1997 Jan;176(1 Pt 1):103-7. doi: 10.1016/s0002-9378(97)80020-8.
We examined whether the risks of hospitalization for ectopic pregnancy and pelvic inflammatory disease increase with increasing numbers of chlamydial infections.
A retrospective cohort design was used to evaluate the risks of hospitalization for ectopic pregnancy or pelvic inflammatory among 11,000 Wisconsin women who had one or more chlamydial infections between 1985 and 1992. Logistic regression was used to evaluate the strength of association between recurrent infection and sequelae.
After adjustment in multivariate analyses, we observed elevated risks of ectopic pregnancy among women who had two (odds ratio 2.1, 95% confidence interval 1.3 to 3.4) and three or more chlamydial infections (odds ratio 4.5, 95% confidence interval 1.8 to 5.3). These groups were also at increased risk for pelvic inflammatory (two infections: odds ratio 4.0, 95% confidence interval 1.6 to 9.9; three or more infections: odds ratio 6.4, 95% confidence interval 2.2 to 18.4).
A unique prevention opportunity occurs at the diagnosis of any chlamydial infection because women with subsequent recurrences are at increased risk for reproductive sequelae.
我们研究了宫外孕和盆腔炎住院风险是否会随着衣原体感染次数的增加而上升。
采用回顾性队列设计，评估1985年至1992年间有一次或多次衣原体感染的11000名威斯康星州女性发生宫外孕或盆腔炎的住院风险。采用逻辑回归分析来评估反复感染与后遗症之间的关联强度。
在多变量分析调整后，我们观察到有两次衣原体感染的女性发生宫外孕的风险升高（比值比2.1，95%置信区间1.3至3.4），有三次或更多次衣原体感染的女性风险更高（比值比4.5，95%置信区间1.8至5.3）。这些女性发生盆腔炎的风险也有所增加（两次感染：比值比4.0，95%置信区间1.6至9.9；三次或更多次感染：比值比6.4，95%置信区间2.2至18.4）。
在诊断任何衣原体感染时都存在独特的预防机会，因为后续复发的女性发生生殖系统后遗症的风险会增加。
