Gibril F, Curtis L T, Termanini B, Fritsch M K, Lubensky I A, Doppman J L, Jensen R T
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Gastroenterology. 1997 Feb;112(2):567-74. doi: 10.1053/gast.1997.v112.pm9024311.
Primary cardiac tumors are rare, and there are no reports of patients with a functional gastroenteropancreatic tumor syndrome caused by such a tumor. This case report describes a patient with a cardiac gastrinoma causing Zollinger-Ellison syndrome. Evidence is presented that this tumor represents a primary cardiac tumor. The exact identification of this gastrinoma in an extra-abdominal site was facilitated by the use of [111In-DTPA-DPhe1]octreotide scanning for somatostatin receptors, which these tumors characteristically possess in high numbers. The recent availability of this novel localization method may facilitate identification of extra-abdominal sites in an increasing proportion of patients with gastrinomas and related neuroendocrine functional tumors in which no intra-abdominal primary tumor is currently found.
原发性心脏肿瘤很罕见，目前尚无原发性心脏肿瘤导致胃肠胰功能性肿瘤综合征的病例报道。本病例报告描述了一名患有导致卓-艾综合征的心脏胃泌素瘤患者。有证据表明该肿瘤为原发性心脏肿瘤。[111In-DTPA-DPhe1]奥曲肽扫描用于检测生长抑素受体，这些肿瘤通常大量表达该受体，这有助于在腹外部位准确识别这种胃泌素瘤。这种新型定位方法的出现，可能有助于在越来越多目前未发现腹内原发性肿瘤的胃泌素瘤及相关神经内分泌功能性肿瘤患者中识别腹外部位。
