Schneider L S
Department of Psychiatry and the Behavioral Sciences, School of Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.
J Clin Psychiatry. 1996;57 Suppl 14:30-6.
Therapeutic approaches to treat the cognitive impairment in dementia and to treat slow decline are making their way into clinical practice. Cholinergic agents are currently the most promising treatment, and several cholinesterase inhibitors will soon be available for prescription. As physicians learn more about dosing, side effects, and mechanisms of action, they can prescribe these drugs more efficiently. Evidence suggests that certain patients with dementia may be particularly responsive to such intervention, and other medications may enhance response. Current experimental approaches to slowing the rate of cognitive decline include the use of antioxidants, monoamine oxidase-B inhibitors, cholinesterase inhibitors, and anti-inflammatory agents. Psychosocial interventions appear to help delay institutionalization. Drugs that improve cognition also may affect behavioral symptoms and severe dementia as well as non-Alzheimer dementia.
治疗痴呆症认知障碍以及延缓缓慢衰退的治疗方法正在进入临床实践。胆碱能药物目前是最有前景的治疗方法，几种胆碱酯酶抑制剂即将可供处方使用。随着医生对给药剂量、副作用和作用机制了解得更多，他们可以更有效地开这些药。有证据表明，某些痴呆症患者可能对这种干预特别敏感，其他药物可能会增强反应。目前减缓认知衰退速度的实验方法包括使用抗氧化剂、单胺氧化酶 - B抑制剂、胆碱酯酶抑制剂和抗炎药。心理社会干预似乎有助于延迟入住养老院。改善认知的药物也可能影响行为症状、重度痴呆以及非阿尔茨海默病性痴呆。
