Beermann B, Groschinsky-Grind M, Lindström B
Clin Pharmacol Ther. 1977 Oct;22(4):385-8. doi: 10.1002/cpt1977224385.
Bendroflumethiazide (bft), 10 mg, was administered orally to 9 healthy volunteers. The concentrations of the diuretic in plasma and urine were determined by gas-liquid chromatography (GLC). Peak plasma levels (86 +/- 18 ng/ml) of bft were reached at 2 +/- 0.4 hr. The concentration declined with a mean t1/2 of 3.0 hr. The apparent volume of distribution averaged 1.48 L/kg. The major part of the drug was eliminated via nonrenal mechanisms, the nonrenal clearance being estimated to 269 +/- 77 ml/min and renal clearance to 105 +/- 24 ml/min. Urinary recovery of the thiazide averaged 30%.
给9名健康志愿者口服10毫克苄氟噻嗪（bft）。通过气液色谱法（GLC）测定血浆和尿液中利尿剂的浓度。bft的血浆峰值水平（86±18纳克/毫升）在2±0.4小时时达到。浓度以平均半衰期3.0小时下降。表观分布容积平均为1.48升/千克。药物的主要部分通过非肾机制消除，非肾清除率估计为269±77毫升/分钟，肾清除率为105±24毫升/分钟。噻嗪类药物的尿回收率平均为30%。
