Lieber M R, Grawunder U, Wu X, Yaneva M
Division of Molecular Oncology, Departments of Pathology, Biochemistry and Molecular Biophysics, Campus Box 8118, Washington University Schoolof Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
Curr Opin Genet Dev. 1997 Feb;7(1):99-104. doi: 10.1016/s0959-437x(97)80116-5.
A convergence of information from biochemistry, yeast and mammalian genetics, immunology, and radiation biology has permitted identification of some of the protein participants - Ku, DNA-PK, XRCC4 - and the reaction intermediates in DNA end joining, suggesting how broken chromosomal ends may be recognized and repaired in eukaryotic cells. Some components may be defective in inherited disorders.
来自生物化学、酵母和哺乳动物遗传学、免疫学以及辐射生物学的信息汇聚，使得人们能够鉴定出一些参与蛋白质——Ku、DNA依赖蛋白激酶（DNA-PK）、X射线修复交叉互补蛋白4（XRCC4）——以及DNA末端连接中的反应中间体，这表明了真核细胞中断裂的染色体末端是如何被识别和修复的。某些成分在遗传性疾病中可能存在缺陷。
