Correa S D, Schaefer S
Department of Internal Medicine, University of California, Davis 95616, USA.
Am J Cardiol. 1997 Jan 1;79(1):75-8. doi: 10.1016/s0002-9149(96)00681-9.
The role of adenosine triphosphate-sensitive potassium channels in the adaptive response to demand ischemia was tested in 22 patients treated with placebo or glibenclamide before sequential exercise testing or atrial pacing. Glibenclamide did not affect the improvement in signs of ischemia in both protocols, indicating that opening of these channels is not a mechanism of this adaptive response in humans.
在22例接受安慰剂或格列本脲治疗的患者中，于序贯运动试验或心房起搏前，对三磷酸腺苷敏感性钾通道在适应需求性缺血反应中的作用进行了测试。格列本脲在两种方案中均未影响缺血征象的改善，这表明这些通道的开放并非人类这种适应性反应的机制。
