Schmutz S M, Moker J S, Clark E G, Orr J P
Department of Animal and Poultry Science, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
J Vet Diagn Invest. 1996 Jan;8(1):91-5. doi: 10.1177/104063879600800114.
Pericardial sac samples from 77 bovine aborted fetuses and stillborn calves were submitted for tissue culture; cells from 55 of these samples were grown successfully in culture. Six of the 55 karyotyped fetuses (10.7%) had an abnormal chromosome complement, in 3 of which (5.5%) the abnormality was probably the cause of death. This level of abnormality is relatively high when one considers that most fetuses were >8 months gestational age. Approximately 5-7% of human stillbirths and 50% of first-trimester aborted fetuses have chromosome anomalies. If a similar situation exists in cattle, as suggested by these data, chromosome abnormalities may be a major cause of early fetal loss in cattle. Most chromosomally abnormal fetuses had multiple malformations, which suggests that the diagnostic use of chromosome analysis is most cost effective for malformed fetuses and newborns. Twins were present in a higher proportion of these fetuses than expected based on their incidence among liveborn cattle.
来自77头流产牛胎儿和死产犊牛的心包囊样本被送去进行组织培养；其中55个样本的细胞在培养中成功生长。在55个进行了核型分析的胎儿中，有6个（10.7%）染色体组成异常，其中3个（5.5%）的异常可能是死亡原因。考虑到大多数胎儿的 gestational age >8个月，这个异常水平相对较高。大约5 - 7%的人类死产和50%的孕早期流产胎儿有染色体异常。如果这些数据表明牛中存在类似情况，那么染色体异常可能是牛早期胎儿丢失的主要原因。大多数染色体异常的胎儿有多种畸形，这表明染色体分析对畸形胎儿和新生儿的诊断用途最具成本效益。这些胎儿中双胞胎的比例高于根据其在活产牛中的发生率所预期的比例。
