Borovskaia T G, Smirnova M E, Filippova M V, Fomina T I, Gol'dberg V E
Eksp Klin Farmakol. 1996 Jul-Aug;59(4):40-2.
Experiments on Wistar rats studied the state of the posterity born as a result of mating of intact females with males, who were injected with the antitumor drug platidiam one month before mating (once, intravenously, maximal tolerance dose). The pre- and postimplantation death rate did not grow in female rats mated with test males. However, the fetuses showed visceral anomalies and delayed development of skeleton. A decrease in the muscle tone, as well as ability for the training and extrapolation behavior, were observed in some newborn rat pups.
对Wistar大鼠进行的实验研究了完整雌性大鼠与在交配前一个月注射抗肿瘤药物顺铂（一次，静脉注射，最大耐受剂量）的雄性大鼠交配所产后代的状况。与受试雄性大鼠交配的雌性大鼠的植入前和植入后死亡率并未增加。然而，胎儿出现了内脏异常和骨骼发育延迟的情况。在一些新生大鼠幼崽中观察到肌肉张力下降以及训练和推理行为能力下降。
