Andreeva N I, Golovina S M, Parimbetova R B, Mashkovskiĭ M D
Eksp Klin Farmakol. 1996 Jul-Aug;59(4):5-7.
Tetrindol, a selective inhibitor of MAOA (predominantly of serotonin oxidase) and fluoxetine, an inhibitor of serotonin neuronal uptake, were studied in psychotropic tests on mice and rats. Both drugs significantly intensified 5-hydroxytriptophan-induced head twitching, reduced the effect of reserpine and the destructive action of maximal electroshock and the scopalamine-induced transient disruption of memory in a test for conditioned response of passive avoidance in rats and mice. In a behavioral swimming test the drugs were less active. In potentiation of 5-HT activity both drugs were approximately equal.
对小鼠和大鼠进行了精神药理学试验，研究了单胺氧化酶（主要是血清素氧化酶）的选择性抑制剂泰尔茚朵和血清素神经元摄取抑制剂氟西汀。两种药物均显著增强了5-羟色氨酸诱导的头部抽搐，减轻了利血平的作用以及最大电击的破坏作用，并在大鼠和小鼠的被动回避条件反应试验中减轻了东莨菪碱诱导的记忆短暂破坏。在行为游泳试验中，两种药物的活性较低。在增强5-羟色胺活性方面，两种药物大致相当。
