关于稳定选择下加性数量性状模型中多态性的一些额外结果。

Some additional results about polymorphisms in models of an additive quantitative trait under stabilizing selection.

作者信息

Gimelfarb A

机构信息

Department of Ecology and Evolution, University of Chicago, IL 60637-1573, USA.

出版信息

J Math Biol. 1996 Nov;35(1):88-96. doi: 10.1007/s002850050044.

DOI:10.1007/s002850050044

PMID:9026554

Abstract

The existence of two stable, symmetric (allelic frequency 0.5 in each locus) polymorphic states is demonstrated for a two-locus model of an additive quantitative trait under strong Gaussian selection. Linkage disequilibrium at one of the states is negative whereas it is positive at the other state. For a three-locus model, it is shown that in order to maintain a stable polymorphism in all three loci, selection must be sufficiently but not excessively strong relative to recombination. Also, positive linkage disequilibrium can be maintained in a three-locus model under stabilizing selection that is not very strong.

摘要

在强高斯选择下，针对加性数量性状的双基因座模型，证明了存在两种稳定、对称（每个基因座上等位基因频率为0.5）的多态状态。其中一种状态下的连锁不平衡为负，而在另一种状态下为正。对于三基因座模型，结果表明，为了在所有三个基因座中维持稳定的多态性，相对于重组而言，选择必须足够强但不能过强。此外，在不太强的稳定选择下，三基因座模型中可以维持正的连锁不平衡。