Danieli G, Gabrielli A, Montroni M, Candela M, Pomponio G, Danieli M G, Fraticelli P, Carratelli R
Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Università, Ancona.
Recenti Prog Med. 1996 Oct;87(10):471-5.
In this paper we considered different models concerning the clinical expression of neuropsychiatric involvement in course of systemic lupus erythematosus (SLE). These models describe pathological conditions as multifocal cerebropathy, transverse myelitis, peripheral neuropathy and panic attacks. We have chosen these cases as clinical example of different pathogenic mechanisms responsible of CNS-lupus, as hypercoagulation due to antiphospholipid syndrome, immune-complex vasculitis, complement-mediated autoantibody damage and antibody-induced cytotoxicity. The prevalence of neuropsychiatric manifestations in 122 SLE patients is also reported. Finally, the paper reports some guidelines about diagnostic and therapeutic behaviour in course of CNS-lupus.
在本文中，我们考虑了关于系统性红斑狼疮（SLE）病程中神经精神受累临床表现的不同模型。这些模型将病理状况描述为多灶性脑病、横贯性脊髓炎、周围神经病变和惊恐发作。我们选择这些病例作为中枢神经系统狼疮不同致病机制的临床实例，如抗磷脂综合征导致的高凝状态、免疫复合物性血管炎、补体介导的自身抗体损伤和抗体诱导的细胞毒性。本文还报告了122例SLE患者神经精神表现的患病率。最后，本文报告了一些关于中枢神经系统狼疮病程中诊断和治疗行为的指南。
