Tareeva I E, Kozlovskaia N L, Krylova M Iu, Rogov V A, Zozulia O V, Ponomarenko I N, Sidorova I S, Makarov I O, Artem'eva V B, Detinkina G N
Ter Arkh. 1996;68(10):52-5.
To assess platelet changes in pregnant women with chronic glomerulonephritis (CGN) and essential hypertension (EH) we estimated platelet lactic dehydrogenase activity (LDH), beta-thromboglobulin and thromboxane B2 (TxB2) plasma levels and ADP-stimulated platelet aggregability. Five groups of gravidae (26-40 weeks of gestation) were studied: with EH (n = 20), with CGN and hypertension (n = 31), with CGN without hypertension (n = 29), with late toxemia (n = 11), nonpregnant CGN women (n = 10) and healthy pregnant women (n = 20). Activation of platelet function was found in gravidae with CGN and EH. Platelet disorders were especially pronounced in pregnant women with CGN and with EH, but they were less pronounced than in control group with late toxemia. We believe that hypertension is more important stimulating factor for platelet activation than renal disease. We suggest that platelet disorders in outpatients are brought about by endothelium damage caused by elevated blood pressure.
为评估慢性肾小球肾炎（CGN）和原发性高血压（EH）孕妇的血小板变化，我们测定了血小板乳酸脱氢酶活性（LDH）、β-血小板球蛋白和血栓素B2（TxB2）的血浆水平以及ADP刺激的血小板聚集性。研究了五组孕妇（妊娠26 - 40周）：患有EH的孕妇（n = 20）、患有CGN和高血压的孕妇（n = 31）、患有CGN但无高血压的孕妇（n = 29）、患有晚期先兆子痫的孕妇（n = 11）、非妊娠CGN女性（n = 10）以及健康孕妇（n = 20）。发现患有CGN和EH的孕妇存在血小板功能激活。血小板紊乱在患有CGN和EH的孕妇中尤为明显，但比晚期先兆子痫对照组的情况要轻。我们认为，高血压比肾脏疾病更重要，是血小板激活的刺激因素。我们建议，门诊患者的血小板紊乱是由血压升高导致的内皮损伤引起的。
