Rogov V A, Zozulia O V, Tareeva I E, Sidorova I S, Makarov I O, Zhuravlev A V, Shipkova T I, Gertner L K, Beĭlin A L, Belitskaia S G
Ter Arkh. 1995;67(5):24-7.
Time course of 187 pregnancies was followed up in 103 females with chronic renal diseases (CRD), 76 females with essential hypertension (EH) and 14 posteclampsia females. Three variants of arterial pressure (AP) and 5 types of proteinuria changes were recognized in CRD and EH patients. The pattern of these changes was compared to that in posteclampsia patients, the eclampsia being an absolute criterium of late toxicosis. It is shown that neither elevated AP and proteinuria nor their absolute values can serve reliable signs of late gestosis in CRD and EH patients. Only the trend in these parameters is significant. CRD and EH females with late gestosis exhibit rapidly growing proteinuria in line with the onset or exacerbation of EH. Retrospective analysis of the pregnancies has confirmed association of late gestosis in 15% of EH and 7% of chronic glomerulonephritis patients. These estimates are lower than commonly accepted. Early diagnosis of late gestosis in pregnant females with CRD and EH requires not only regular AP registration, but also dynamic, in some cases hourly, evaluation of proteinuria.
对103例慢性肾病（CRD）女性、76例原发性高血压（EH）女性和14例先兆子痫女性的187次妊娠过程进行了随访。在CRD和EH患者中识别出三种动脉压（AP）变化类型和五种蛋白尿变化类型。将这些变化模式与先兆子痫患者的变化模式进行了比较，子痫是晚期中毒的绝对标准。结果表明，无论是升高的AP和蛋白尿，还是它们的绝对值，都不能作为CRD和EH患者晚期妊娠中毒的可靠指标。只有这些参数的变化趋势具有显著性。患有晚期妊娠中毒的CRD和EH女性，随着EH的发作或加重，蛋白尿迅速增加。对这些妊娠的回顾性分析证实，15%的EH患者和7%的慢性肾小球肾炎患者存在晚期妊娠中毒的关联。这些估计值低于普遍接受的数值。对患有CRD和EH的妊娠女性进行晚期妊娠中毒的早期诊断，不仅需要定期记录AP，还需要在某些情况下每小时动态评估蛋白尿。
