Kressin M, Sommer U
Institut für Veterinär-Anatomie, -Histologie und -Embryologie der Justus-Liebig-Universität Giessen, Deutschland.
Anat Histol Embryol. 1996 Sep;25(3):177-86. doi: 10.1111/j.1439-0264.1996.tb00080.x.
The differentiation of the surface mucous-cell lineage during physiological cell renewal was investigated using light and electron microscopy in the abomasal mucosa of adult cattle. The surface mucous cells constitute a morphologically and functionally heterogeneous population, whose members correspond to different developmental stages, OFFanged in a distoproximal gradient from the depth of the pit towards the free luminal surface. The cell lineage comprises immature pre-pit cells near the proliferative isthmus, mature pit cells within the foveola, and older interfoveolar cells lining the free surface. Ultrastructurally, differentiation can be traced towards a predominantly mucus-producing cell type and finally towards a surface-protective cell variant, which degenerates in situ and is extruded into the lumen without affecting epithelial integrity.
利用光镜和电镜对成年牛皱胃黏膜生理细胞更新过程中表面黏液细胞谱系的分化进行了研究。表面黏液细胞构成了一个形态和功能上异质性的群体，其成员对应于不同的发育阶段，从隐窝底部向游离腔面呈远侧近侧梯度排列。细胞谱系包括增殖峡部附近的未成熟隐窝前细胞、小凹内的成熟隐窝细胞以及游离表面衬里的较老的小凹间细胞。在超微结构上，分化可追溯到主要产生黏液的细胞类型，最终形成表面保护细胞变体，该变体原位退化并被挤出到管腔中，而不影响上皮完整性。
