Kressin M
Department of Veterinary Anatomy, Histology and Embryology, University of Giessen, Germany.
Anat Histol Embryol. 1997 Sep;26(3):217-22. doi: 10.1111/j.1439-0264.1997.tb00129.x.
The ultrastructural differentiation and maturation of the neck cells and the zymogenic cells during physiological cell renewal were investigated in the abomasal oxyntic-gland region of cattle. Immature neck cells of the distal isthmus and proximal neck exhibit transitional morphology to the predominantly mucous isthmus cells. Neck cells confined to the glandular neck are characterized by bipartite peptic-cored mucous secretory granules. In a proximal-distal gradient along the neck, a progressive increase in the peptic granular component and concomitant reduction in mucous components paralleled by proliferation of the rough endoplasmic reticulum creates pre-zymogenic cells in the proximal glandular base. These, in turn, give rise to mature zymogenic cells with pure peptic secretory granules and typical zymogenic cell morphology. In the depth of the gland, older degenerative zymogenic cells are found. Variations in size and number of the zymogenic granules point to different secretory activities of the mature zymogenic-cell population of the glandular base. These results favour the conception of a zymogenic-cell lineage arising within the isthmus and passing through different developmental stages, including neck cells, during their migration down the gland.
对牛皱胃泌酸腺区生理细胞更新过程中颈部细胞和胃酶原细胞的超微结构分化与成熟进行了研究。峡部远端和颈部近端的未成熟颈部细胞呈现出向以黏液为主的峡部细胞的过渡形态。局限于腺颈部的颈部细胞的特征是具有二分体的含胃蛋白酶核心的黏液分泌颗粒。沿着颈部从近端到远端的梯度，胃蛋白酶颗粒成分逐渐增加，黏液成分相应减少，同时粗面内质网增殖，在腺底部近端产生前胃酶原细胞。这些前胃酶原细胞进而发育为具有纯胃蛋白酶分泌颗粒和典型胃酶原细胞形态的成熟胃酶原细胞。在腺的深处，发现了较老的退化胃酶原细胞。胃酶原颗粒大小和数量的变化表明腺底部成熟胃酶原细胞群体具有不同的分泌活性。这些结果支持这样一种概念，即胃酶原细胞谱系在峡部产生，并在其沿腺向下迁移的过程中经历包括颈部细胞在内的不同发育阶段。
