[The immunobiochemical mechanisms of the intoxication syndrome in acute diffuse peritonitis].

The course of diffuse peritonitis was studied in 211 patients with the reactive (25 patients), toxic (114), and terminal (65) stages. Besides routine treatment, local abdominal hypothermia, UV exposure of autoblood, and, if indicated, hyperbaric oxygenation and hemoperfusion were used in multiple-modality treatment of these patients. In addition to the common clinical tests, immunobiochemical monitoring of the function of medium-molecular peptides and index of their distribution, as well as of the fractions of circulating immune complexes and of IgA, IgM, and IgG was used to assess the severity of intoxication and treatment efficacy and predict the disease course and outcome. Intoxication of the organism was shown to lead to the formation of immunity shifts, involving, among other things, the humoral immunity.