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[濒死期及复苏后早期左心室心肌功能状态的变化]

[Changes in the functional status of the left-ventricular myocardium during dying and in the early postresuscitation period].

作者信息

Talantsev K V, Novoderzhkina I S, Kozhura V L, Kirsanova A K, Berezina T L

出版信息

Anesteziol Reanimatol. 1996 Sep-Oct(5):45-8.

PMID:9027255
Abstract

Experiments on dogs have shown that left-ventricular contractility reduces and the processes of contraction and relaxation are discoordinated during the first minutes of dying from acute blood loss with the mean arterial pressure of 40 mm Hg. During the postreanimation period following a ten-min clinical death spontaneous respiration is resumed late (after 15.1 +/- 3.2 min), as are the corneal reflexes (after 46.1 +/- 8.5 min). If there are no changes in left-ventricular contractility in the course of dying, vital functions of the organism and neurological reflexes recover sooner (respiration after 6.1 +/- 2.0 min and corneal reflexes after 32.6 +/- 4.1 min). A relationship has been revealed between the severity of the postreanimation period and the degree of reduction of left-ventricular myocardial contractility during hypoperfusion (1 to 6 hrs after reanimation): the contractility index in animals with late neurologic recovery was lower than in those with a relatively early neurologic recovery.

摘要

对狗的实验表明,在急性失血导致平均动脉压为40毫米汞柱的濒死最初几分钟内,左心室收缩力降低,收缩和舒张过程失调。在经历10分钟临床死亡后的复苏期,自主呼吸恢复较晚(15.1±3.2分钟后),角膜反射也是如此(46.1±8.5分钟后)。如果在濒死过程中左心室收缩力没有变化,机体的生命功能和神经反射恢复得更快(呼吸在6.1±2.0分钟后恢复,角膜反射在32.6±4.1分钟后恢复)。已发现复苏期的严重程度与低灌注期间(复苏后1至6小时)左心室心肌收缩力降低程度之间存在关联:神经功能恢复较晚的动物的收缩力指数低于神经功能恢复相对较早的动物。

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