Korpacheva O V, Dolgikh V T
Anesteziol Reanimatol. 1996 Sep-Oct(5):48-51.
Disorders of systemic hemodynamics and myocardial contractility during the early postresuscitation period were examined in 132 outbred male rats resuscitated after 4-min clinical death from acute blood loss. The efficacy of adding verapamil (calcium ion antagonist) in a dose of 0.1 mg/kg to a complex of reanimation measures was assessed. Verapamil added to resuscitation procedures was conducive to an earlier repair of heart work and to a reduction of the early postresuscitation arrhythmias; it ensured a hemodynamic relief of the heart and decreased cardiodepression. Cardioprotective effect of verapamil was due to its ability to protect cell membranes from irreversible ischemic and reperfusion damage by preventing the postresuscitation calcium overloading of cardiomyocytes.
对132只杂种雄性大鼠进行研究，这些大鼠在因急性失血导致4分钟临床死亡后复苏，观察复苏后早期全身血流动力学和心肌收缩力的紊乱情况。评估了在复苏措施组合中添加剂量为0.1mg/kg的维拉帕米（钙离子拮抗剂）的效果。添加到复苏程序中的维拉帕米有助于心脏功能更早恢复，并减少复苏后早期心律失常；它确保了心脏的血流动力学缓解并减轻了心脏抑制。维拉帕米的心脏保护作用归因于其能够通过防止复苏后心肌细胞钙超载来保护细胞膜免受不可逆的缺血和再灌注损伤。
