Kalninia I E, Baumanis E A, Mikazhans V D, Fateev V A, Baltkaĭs Ia Ia
Farmakol Toksikol. 1977 Jul-Aug;40(4):393-7.
In experiments on guinea pigs it is shown that a preliminary intraperitoneal administration of monoamine oxidase inhibitors (MAOI) -- transamine (10 mg/kg) or malic acid benzyldihydrazide (50 mg/kg) antagonizes the local anesthetic action of celnovocaine (CC) and novocaine (NC). An analogous effect is also observed following instillation of transamine (a 0.1% solution) and malic acid benzyldihydrazide (a 0.23% solution) into the eye 10 minutes before administration of the anesthetic. Instillation of a 0.1% serotonin creatinine sulphate solution also antagonizes anesthesia produced by CC and NC, while MAOI potentiates the effect of serotonin.
在豚鼠实验中表明，预先腹腔注射单胺氧化酶抑制剂（MAOI）——反胺（10毫克/千克）或苹果酸苄基二酰肼（50毫克/千克）可拮抗赛罗卡因（CC）和奴夫卡因（NC）的局部麻醉作用。在麻醉剂给药前10分钟，将反胺（0.1%溶液）和苹果酸苄基二酰肼（0.23%溶液）滴入眼中，也观察到类似效果。滴入0.1%的血清素硫酸肌氨酸溶液也可拮抗CC和NC产生的麻醉作用，而MAOI可增强血清素的作用。
