Baumanis E A, Plaude O O, Buikis I M
Vopr Onkol. 1978;24(9):71-7.
There was found a correlation between dynamic changes in the serotonin level and mortality in rats with 9,10-dimethyl-1,2-benzanthracene induced blastomogenesis. An estimation was made of the influence of monoamine oxidase inhibitors, transamine and D, L-malic acid benzyldihydrazide on the type of a tumor produced. Chemical blastomogenesis in the case of cerebellar tumors is shown to be associated with the decreased serotonin content at the site of a tumor. But fluctuations of the serotonin level in the hypothalamus have not been detected. This evidenced that the decreased mortality rate caused by the administration of monoamine oxidase inhibitor is due to a lower production of astrocytomas and genetically related glioblastomas. The role of serotonin in increasing the astrocyte resistance to malignant degeneration has been discussed.
在9,10-二甲基-1,2-苯并蒽诱导的大鼠肿瘤发生过程中，发现血清素水平的动态变化与死亡率之间存在相关性。评估了单胺氧化酶抑制剂、转胺和D,L-苹果酸苄基二酰肼对所产生肿瘤类型的影响。结果表明，小脑肿瘤的化学性肿瘤发生与肿瘤部位血清素含量降低有关。但未检测到下丘脑中血清素水平的波动。这证明，单胺氧化酶抑制剂给药导致的死亡率降低是由于星形细胞瘤和遗传相关胶质母细胞瘤的产生减少。文中讨论了血清素在增强星形胶质细胞对恶性变性的抵抗力中的作用。
