正常对照者和播散性肿瘤患者血清中透明质酸酶活性与透明质酸浓度之间的关系。

The relationship between hyaluronidase activity and hyaluronic acid concentration in sera from normal controls and from patients with disseminated neoplasm.

作者信息

Wilkinson C R, Bower L M, Warren C

机构信息

Department of Chemical Pathology, Torbay Hospital, UK.

出版信息

Clin Chim Acta. 1996 Dec 30;256(2):165-73. doi: 10.1016/s0009-8981(96)06421-2.

DOI:10.1016/s0009-8981(96)06421-2

PMID:9027427

Abstract

Serum hyaluronidase activity (HAE) and hyaluronic acid (HA) concentration were measured in sera from patients with disseminated neoplasm and compared to those of normal controls. The serum HAE activity in disseminated neoplasm (mean, 12.6 mumol N-acetylglucosamine (NAG)/min/1; range, 5.2-24.7 mumol NAG/min/1) was significantly lower (t = 6.7, p < 0.001) than in normal controls (mean, 17.1 mumol NAG/min/1; range, 11.5-27.0 mumol NAG/min/1). The serum HA concentration in patients with disseminated neoplasm (mean, 8199.7 micrograms/l; range, 42.0-496,000 micrograms/l) was significantly higher (t = 2.63, 0.01 > p> 0.001) than in normal age-matched controls (mean, 55.6 micrograms/l; range, 10.0-348.0 micrograms/l). A negative correlation was found between the serum HAE activity and the HA concentration (r = -0.45, t = 5.92, p < 0.001). The possible reasons for the low serum HAE activity and the raised serum HA concentration in patients with disseminated neoplasm and the negative correlation between the results are discussed.

摘要

检测了播散性肿瘤患者血清中的透明质酸酶活性（HAE）和透明质酸（HA）浓度，并与正常对照组进行比较。播散性肿瘤患者的血清HAE活性（平均值为12.6 μmol N-乙酰葡糖胺（NAG）/分钟/1；范围为5.2 - 24.7 μmol NAG/分钟/1）显著低于正常对照组（平均值为17.1 μmol NAG/分钟/1；范围为11.5 - 27.0 μmol NAG/分钟/1）（t = 6.7，p < 0.001）。播散性肿瘤患者的血清HA浓度（平均值为8199.7 μg/l；范围为42.0 - 496,000 μg/l）显著高于年龄匹配的正常对照组（平均值为55.6 μg/l；范围为10.0 - 348.0 μg/l）（t = 2.63，0.01 > p > 0.001）。血清HAE活性与HA浓度之间呈负相关（r = -0.45，t = 5.92，p < 0.001）。讨论了播散性肿瘤患者血清HAE活性降低和血清HA浓度升高的可能原因以及结果之间的负相关关系。