与类风湿关节炎患者相比，银屑病关节炎患者血清透明质酸水平较低。

Low serum hyaluronan in psoriatic arthritis patients in comparison to rheumatoid arthritis patients.

作者信息

Partsch G, Leeb B, Stancikova M, Raffayova H, Eberl G, Hitzelhammer H, Smolen J S

机构信息

Ludwig Boltzmann Institute of Rheumatology and Balneology, Vienna-Oberlaa, Austria.

出版信息

Clin Exp Rheumatol. 1996 Jul-Aug;14(4):381-6.

PMID:8871836

Abstract

OBJECTIVE

Serum hyaluronan (HA) was determined in 37 patients suffering from psoriatic arthritis (PSA), 39 patients with rheumatoid arthritis (RA), 31 with osteoarthritic joint disease (OA) and 26 healthy controls (C) in order to examine earlier reports that HA levels are increased in the serum of RA and to assess whether this finding is also relevant for PSA, another inflammatory joint disease, since HA in serum is considered a sign of inflammation in general.

METHOD

HA in the serum samples was measured with an enzyme linked microplate assay.

RESULTS

Sera from PSA, RA and OA patients showed a significantly higher HA concentration than those of healthy controls (56.0 +/- 16.0 micrograms/l). The serum HA concentration in PSA patients amounted to 107.8 +/- 57.2 micrograms/l, which was not significantly different from OA patients (104.9 +/- 16 micrograms/l). A significant difference, however, could be observed between the HA concentrations of the PSA subgroups: the mean HA level of patients suffering from symmetrical polyarthritis was 134 +/- 79.6 micrograms/l, which turned out to be significantly higher than in patients suffering from symmetrical oligoarthritis (89.9 +/- 42.8 micrograms/l; P < 0.04), but was insignificantly increased in comparison to patients with ankylosing spondylitis as the predominant feature (109 +/- 27.8 micrograms/l; P = 0.49). The mean HA concentration for RA sera was 197.1 +/- 122.9 micrograms/l, which was statistically significantly increased compared to PSA (P < 0.001) and OA (P < 0.001) sera. The sera of seropositive RA patients showed significantly higher HA levels than PSA patients with symmetrical polyarthritis (P < 0.04).

CONCLUSION

The data obtained support recent studies which have shown HA levels to be higher in RA patients than in OA patients. Seronegative and seropositive RA patients showed the same HA concentrations, while patients suffering from "seronegative" PSA were found to have lower HA concentrations. Therefore, HA serum levels may reflect cartilage degradation in general or the degree of articular inflammatory processes, indicating different pathogenetic pathways.

摘要

目的

测定37例银屑病关节炎（PSA）患者、39例类风湿关节炎（RA）患者、31例骨关节炎关节病（OA）患者及26例健康对照者（C）的血清透明质酸（HA），以检验先前关于RA患者血清中HA水平升高的报道，并评估这一发现是否也与另一种炎性关节病PSA相关，因为血清中的HA通常被视为炎症的一个标志。

方法

采用酶联微孔板分析法测定血清样本中的HA。

结果

PSA、RA和OA患者血清中的HA浓度显著高于健康对照者（56.0±16.0微克/升）。PSA患者血清HA浓度为107.8±57.2微克/升，与OA患者（104.9±16微克/升）无显著差异。然而，在PSA亚组的HA浓度之间可观察到显著差异：对称性多关节炎患者的平均HA水平为134±79.6微克/升，显著高于对称性少关节炎患者（89.9±42.8微克/升；P<0.04），但与以强直性脊柱炎为主要特征的患者相比升高不显著（109±27.8微克/升；P=0.49）。RA血清的平均HA浓度为197.1±122.9微克/升，与PSA（P<0.001）和OA（P<0.001）血清相比有统计学显著升高。血清阳性RA患者的血清HA水平显著高于对称性多关节炎的PSA患者（P<0.04）。