Göpfert T, Eckardt K U, Geb B, Kurtz A
Physiologisches Institut, Universität, Regensburg, Germany.
Kidney Int. 1997 Feb;51(2):502-6. doi: 10.1038/ki.1997.70.
The essential role of the glycoprotein hormone erythropoietin (Epo) in the control of red blood cell production is well established. Synthesis of Epo is induced in response to low oxygen (hypoxia). In response to stimulation, increases in serum Epo levels are paralleled by changes in the abundance of Epo mRNA. These changes indicate that the level of Epo mRNA is the major determinant of hormone production rate [1-3]. Studies of the organ distribution of Epo mRNA [4, 5] have confirmed the results of organ ablation studies, which demonstrated that in adults the kidney is the major organ responsible for the Epo production, but the liver is capable of Epo production as well [6, 7]. More sensitive detection methods of Epo mRNA have demonstrated small quantities in testis, brain, lung, and spleen of rodents [3, 8].
糖蛋白激素促红细胞生成素（Epo）在控制红细胞生成中的重要作用已得到充分证实。Epo的合成是对低氧（缺氧）的反应而被诱导的。在受到刺激时，血清Epo水平的升高与Epo mRNA丰度的变化平行。这些变化表明Epo mRNA的水平是激素产生速率的主要决定因素[1-3]。对Epo mRNA器官分布的研究[4,5]证实了器官切除研究的结果，该研究表明在成年人中，肾脏是负责Epo产生的主要器官，但肝脏也能够产生Epo[6,7]。更灵敏的Epo mRNA检测方法已在啮齿动物的睾丸、脑、肺和脾脏中检测到少量Epo mRNA[3,8]。
