Dantendorfer K, Prayer D, Kramer J, Amering M, Baischer W, Berger P, Schoder M, Steinberger K, Windhaber J, Imhof H, Katschnig H
Department of Psychiatry, University of Vienna, Austria.
Psychiatry Res. 1996 Nov 25;68(1):41-53. doi: 10.1016/s0925-4927(96)03003-x.
The frequency and quality of brain abnormalities in panic disorder (PD) were assessed with magnetic resonance imaging (MRI). The use of electroencephalography (EEG) to detect PD patients with a high probability of morphologic brain abnormalities was also explored. Consecutive PD patients (n = 120) were screened with routine EEG examinations and were divided into the following subgroups on the basis of their EEG findings: patients with non-epileptic EEG abnormalities (EEG-A group, n = 28), matched patients with normal EEG results (EEG-N group, n = 28) and matched healthy controls (n = 28). PD patients showed a higher than expected rate of non-epileptic EEG abnormalities (29.2%; 35 of 120). EEG screening was effective in identifying patients with a high probability of morphologic brain abnormalities. MRI abnormalities were found in 60.7% of the EEG-A patients, 17.9% of the EEG-N patients, and only 3.6% of the controls. A high frequency of septo-hippocampal abnormalities was found. Further research should focus on attempts to subtype PD on the basis of neuroanatomic and functional brain abnormalities.
采用磁共振成像（MRI）评估惊恐障碍（PD）患者脑异常的频率和特征。同时探索利用脑电图（EEG）检测具有较高形态学脑异常可能性的PD患者。对连续纳入的120例PD患者进行常规脑电图检查，并根据脑电图结果分为以下亚组：非癫痫性脑电图异常患者（EEG-A组，n = 28）、脑电图结果正常的匹配患者（EEG-N组，n = 28）和匹配的健康对照者（n = 28）。PD患者出现非癫痫性脑电图异常的比例高于预期（29.2%；120例中有35例）。脑电图筛查有助于识别具有较高形态学脑异常可能性的患者。EEG-A组60.7%的患者、EEG-N组17.9%的患者以及对照组仅3.6%的患者发现MRI异常。发现海马旁隔异常的频率较高。进一步的研究应致力于根据神经解剖学和功能性脑异常对PD进行亚型分类。
