Russi M, Dubrow R, Flannery J T, Cullen M R, Mayne S T
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Am J Ind Med. 1997 Feb;31(2):166-71. doi: 10.1002/(sici)1097-0274(199702)31:2<166::aid-ajim5>3.0.co;2-y.
This death certificate-based case-control study linked Connecticut Tumor Registry and Connecticut Division of Vital Statistics death data to determine whether machining fluid exposure is associated with laryngeal cancer risk. Laryngeal cancer cases were compared with oral cancer controls and general population controls. Level of exposure to machining fluids was imputed from the usual occupation and industry on the death certificate. Because exposure was infrequent among females, analysis was limited to males. When cases were compared to oral cancer controls, high exposure to machining fluids was associated with laryngeal cancer (odds ratio = 1.48; 95% confidence interval = 1.01-2.16), with a p-value for trend of 0.08. When cases were compared to population controls, no association between machining fluid exposure and laryngeal cancer was observed. A possible reason for the contrasting results, other than chance, is that exposure data quality for the cases and oral cancer controls may have differed from that of the population controls.
这项基于死亡证明的病例对照研究将康涅狄格肿瘤登记处和康涅狄格生命统计部门的死亡数据相联系，以确定接触加工液是否与喉癌风险相关。将喉癌病例与口腔癌对照和一般人群对照进行比较。加工液暴露水平根据死亡证明上的通常职业和行业估算得出。由于女性中暴露情况不常见，分析仅限于男性。当将病例与口腔癌对照进行比较时，高暴露于加工液与喉癌相关（比值比 = 1.48；95% 置信区间 = 1.01 - 2.16），趋势的 p 值为 0.08。当将病例与人群对照进行比较时，未观察到加工液暴露与喉癌之间存在关联。除了偶然性之外，结果对比的一个可能原因是，病例和口腔癌对照的暴露数据质量可能与人群对照的不同。
