Vernon S W, Gritz E R, Peterson S K, Amos C I, Perz C A, Baile W F, Lynch P M
University of Texas Health Science Center at Houston School of Public Health 77225, USA.
Health Psychol. 1997 Jan;16(1):73-86. doi: 10.1037//0278-6133.16.1.73.
In this article the authors describe the demographic and psychosocial correlates of 2 measures of psychologic distress among 200 colorectal cancer patients undergoing genetic testing for hereditary nonpolyposis colon cancer. The prevalence of symptoms of depression on the Center for Epidemiologic Studies Depression (CES-D) Scale was 24%. In multivariate analysis, female sex, less formal education, fewer sources of social contacts, and less satisfaction with them were associated with high scores on the CES-D Scale. Characteristics associated with high scores on the State-Trait Anxiety Inventory were younger age, less formal education, non-White race, local-regional stage of disease, fewer social contacts, and less satisfaction with them. Information on psychosocial correlates of psychologic distress may prove useful in guiding genetic counseling sessions, in identifying subgroups that need more intensive follow-up, and in developing interventions to facilitate adjustment to genetic test results.
在本文中，作者描述了200例接受遗传性非息肉病性结直肠癌基因检测的结直肠癌患者中，两种心理困扰测量指标的人口统计学和心理社会相关性。采用流行病学研究中心抑郁量表（CES-D）时，抑郁症状的患病率为24%。多变量分析显示，女性、受正规教育程度较低、社会交往来源较少以及对社交的满意度较低与CES-D量表高分相关。状态-特质焦虑量表高分相关的特征包括年龄较小、受正规教育程度较低、非白人种族、疾病的局部区域分期、社交接触较少以及对社交的满意度较低。心理困扰的心理社会相关性信息可能有助于指导遗传咨询会议、识别需要更密切随访的亚组以及制定促进对基因检测结果适应的干预措施。
