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非意外性损伤:与暂时性脆性骨病和轻度成骨不全的鉴别

Non-accidental injury: confusion with temporary brittle bone disease and mild osteogenesis imperfecta.

作者信息

Ablin D S, Sane S M

机构信息

Department of Radiology, University of California Davis Medical Center, 2516 Stockton Boulevard, Ticon II, Sacramento, CA 95817, USA.

出版信息

Pediatr Radiol. 1997 Feb;27(2):111-3. doi: 10.1007/s002470050079.

DOI:10.1007/s002470050079
PMID:9028840
Abstract

Accurate diagnosis of non-accidental injury (NAI) can be reached in the majority of cases by careful appraisal of the social and family history, combined with painstaking clinical roentgenographic and other imaging evaluations. Careful review of the scientific literature clearly indicates that collagen analysis to exclude mild forms of osteogenesis imperfecta, especially type IV, is recommended only in rare cases in which diagnosis of NAI remains in doubt even after thorough evaluation by experienced radiologists and/or other physicians. Until clinical research scientifically establishes the existence of temporary brittle bone disease, it should remain strictly a hypothetical entity and not an acceptable medical diagnosis.

摘要

在大多数情况下,通过仔细评估社会和家族史,结合细致的临床X线及其他影像学评估,可准确诊断非意外伤害(NAI)。对科学文献的仔细回顾清楚地表明,仅在极少数情况下,即在经验丰富的放射科医生和/或其他医生进行全面评估后NAI诊断仍存疑问时,才建议进行胶原蛋白分析以排除轻度成骨不全症,尤其是IV型。在临床研究科学证实暂时性脆性骨病的存在之前,它应严格保持为一种假设的实体,而不是可接受的医学诊断。

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Distinct biochemical phenotypes predict clinical severity in nonlethal variants of osteogenesis imperfecta.不同的生化表型可预测成骨不全非致死性变异的临床严重程度。
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