Mitchell G F, Pfeffer M A, Finn P V, Pfeffer J M
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Appl Physiol (1985). 1997 Jan;82(1):203-10. doi: 10.1152/jappl.1997.82.1.203.
We evaluated methods for measuring average and regional pulse-wave velocity along the full length of the aorta in 18-mo-old ether-anesthetized male spontaneously hypertensive rats. Catheter-tip manometers were placed in the ascending and descending thoracic aorta via the right carotid and left femoral arteries, respectively. As the distal catheter was withdrawn at 1-cm intervals, the relationship between the distal catheter insertion distance and distance between transducers was determined from the intercept of the insertion distance vs. transmission delay regression line. Methods that assessed the foot-to-foot time delay between pressures accurately predicted the separation between catheters (measured distance of 1.43 cm; intercept of 1.40 +/- 0.5 cm; P = not significant) were highly reproducible (coefficient of variation of 2.3% for repeated measurements) and showed minimal variability (range 509 +/- 30 to 600 +/- 29 cm/s) along the full length of the aorta. Methods that made use of the pressure-pressure transfer function were spatially (range of values along the aorta 367 +/- 17 to 722 +/- 39 cm/s) and temporally more variable, especially during vasoconstriction with methoxamine, due to the effects of reflected waves.
我们评估了在18月龄经乙醚麻醉的雄性自发性高血压大鼠中测量沿主动脉全长的平均和区域脉搏波速度的方法。分别通过右颈动脉和左股动脉将导管尖端压力计置于胸主动脉升部和降部。当以1厘米的间隔撤回远端导管时，根据插入距离与传输延迟回归线的截距确定远端导管插入距离与换能器之间距离的关系。准确评估压力之间足对足时间延迟的方法可高度准确地预测导管之间的间距（测量距离为1.43厘米；截距为1.40±0.5厘米；P值无统计学意义），具有高度可重复性（重复测量的变异系数为2.3%），并且在主动脉全长范围内显示出最小的变异性（范围为509±30至600±29厘米/秒）。利用压力-压力传递函数的方法在空间上（沿主动脉的值范围为367±17至722±39厘米/秒）和时间上变异性更大，尤其是在使用甲氧明进行血管收缩期间，这是由于反射波的影响。
