Suh S W, Kim W G, Kim H C, Min B G
Department of Biomedical Engineering, Seoul National University, Korea.
Int J Artif Organs. 1996 Dec;19(12):712-8.
A new low-cost artificial heart valve with easily modified dimensions according to its application was developed using segmented polyurethane (SPU). It consists of a convex frame and a concave membrane which floats in the center of the frame while working. The hydrodynamic performance of the polymer valve was compared with that of the Björk-Shiley mechanical valve using a mock circulatory testing system. The hydrodynamic performance of this valve was superior to the Björk-Shiley mechanical valve. The valve was applied to a ventricular assist device (VAD) developed in our institute. In vivo performances of these systems were tested using mongrel dogs. During the experiments, there were no complications related to malfunction of the valve. At postmortem examinations, no thrombus formation was found on the valve surface, and no embolus was detected in the kidneys. We believe this valve could prove a very useful alternative for valves of mechanical circulatory support systems (MCSS) such as VAD and TAH.
采用分段聚氨酯（SPU）研发出一种新型低成本人工心脏瓣膜，其尺寸可根据应用情况轻松修改。它由一个凸形框架和一个凹形膜组成，工作时该凹形膜漂浮在框架中心。使用模拟循环测试系统，将这种聚合物瓣膜的流体动力学性能与 Björk-Shiley 机械瓣膜的性能进行了比较。该瓣膜的流体动力学性能优于 Björk-Shiley 机械瓣膜。该瓣膜被应用于我们研究所研发的心室辅助装置（VAD）。使用杂种犬对这些系统的体内性能进行了测试。实验过程中，未出现与瓣膜故障相关的并发症。在尸检时，未在瓣膜表面发现血栓形成，且在肾脏中未检测到栓子。我们相信，对于诸如 VAD 和 TAH 等机械循环支持系统（MCSS）的瓣膜而言，这种瓣膜可能会被证明是一种非常有用的替代品。
