Ogino H, Klangsuk N, Jin W, Bowles C T, Yacoub M H
Heart Science Centre, National Heart and Lung Institute, Harefield Hospital, Middlesex, UK.
Artif Organs. 1995 Jun;19(6):525-34. doi: 10.1111/j.1525-1594.1995.tb02373.x.
The dependence of transient pressure characteristics of a ventricular assist device (VAD) on the compliance of its housing and cannulas was investigated in a mock circulation. The peak rate of change of pressure (dP/dtmax) values was greater in the cannulas than other compartments and was associated with valve closure-induced pressure oscillations. When cannula compliance was increased from 0.0057 to 0.0129 cm3/mm Hg, these values decreased by approximately 20%, and outflow cannula pressure oscillation frequency decreased from 17.5 Hz by 35%. This trend was also apparent in the inflow. A VAD housing compliance increase from 0.0162 to 0.0483 cm3/mm Hg caused a dP/dtmax decrease of 30% in both the blood chamber and the outflow cannula. The effect of this change on the inflow was weaker implying that housing absorbs the energy associated with outflow deceleration more effectively than the inflow. These findings suggest that increasing VAD housing and cannulas compliance can improve hydrodynamic performance.
在模拟循环中研究了心室辅助装置（VAD）的瞬态压力特性对其外壳和插管顺应性的依赖性。插管中的压力变化峰值速率（dP/dtmax）值高于其他腔室，并且与瓣膜关闭引起的压力振荡有关。当插管顺应性从0.0057增加到0.0129 cm³/mm Hg时，这些值下降了约20%，流出插管压力振荡频率从17.5 Hz下降了35%。这种趋势在流入中也很明显。VAD外壳顺应性从0.0162增加到0.0483 cm³/mm Hg导致血腔和流出插管中的dP/dtmax均下降30%。这种变化对流入的影响较弱，这意味着外壳比流入更有效地吸收与流出减速相关的能量。这些发现表明，增加VAD外壳和插管的顺应性可以改善流体动力学性能。
