Baskar S, Hamilton R G, Norman P S, Ansari A A
Johns Hopkins Asthma and Allergy Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md., USA.
Int Arch Allergy Immunol. 1997 Feb;112(2):184-90. doi: 10.1159/000237452.
The peripheral blood mononuclear cells (PBMC) from humans allergic to grass pollens (GR+ subjects) show strong in vitro proliferative responses to purified allergens from Lolium perenne pollen Lol p 1, and to a lesser extent to Lol p 2 and Lol p 3. By contrast, PBMC from grass allergic patients undergoing immunotherapy (GR + IT subjects) exhibit a very poor Lol p-specific proliferative response, similar to that observed in nongrass allergic subjects (GR-subjects). Unlike GR-subjects, both GR+ and GR + IT subjects have high levels of antigen-specific serum IgG and IgE antibodies to Lol p 1, Lol p 2 and Lol p 3. While GR+ subjects exhibit a significant correlation between antigen-specific serum antibody and PBMC responses, GR + IT subjects do not show a correlation between the two responses. The possible mechanisms by which immunotherapy may modulate allergen-specific T cell proliferative response are discussed.
对草花粉过敏的人（GR+受试者）的外周血单个核细胞（PBMC）对黑麦草花粉纯化变应原Lol p 1表现出强烈的体外增殖反应，对Lol p 2和Lol p 3的反应较弱。相比之下，接受免疫治疗的草过敏患者（GR + IT受试者）的Lol p特异性增殖反应非常差，类似于非草过敏受试者（GR-受试者）。与GR-受试者不同，GR+和GR + IT受试者对Lol p 1、Lol p 2和Lol p 3均有高水平的抗原特异性血清IgG和IgE抗体。虽然GR+受试者的抗原特异性血清抗体与PBMC反应之间存在显著相关性，但GR + IT受试者的这两种反应之间没有相关性。本文讨论了免疫治疗可能调节变应原特异性T细胞增殖反应的潜在机制。
